Leonard P Rybak Selected Research

Ototoxicity

11/2021	Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity.
1/2021	Effects of Moringa Extract on Aminoglycoside-Induced Hair Cell Death and Organ of Corti Damage.
1/2021	Ototoxicity of Non-aminoglycoside Antibiotics.
5/2019	Mechanisms of Cisplatin-Induced Ototoxicity and Prevention.
1/2019	Local Drug Delivery for Prevention of Hearing Loss.
1/2019	Oral Administration of Caffeine Exacerbates Cisplatin-Induced Hearing Loss.
1/2018	Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity.
1/2017	Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity.
1/2017	Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.
10/2016	Role of STAT1 and Oxidative Stress in Gentamicin-Induced Hair Cell Death in Organ of Corti.

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Leonard P Rybak Research Topics

Disease

35	Ototoxicity 11/2021 - 06/2002
24	Hearing Loss (Hearing Impairment) 11/2021 - 06/2002
17	Neoplasms (Cancer) 05/2019 - 08/2002
8	Inflammation (Inflammations) 11/2021 - 01/2006
3	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 01/2012
3	Blister (Bulla) 05/2004 - 03/2003
2	Noise-Induced Hearing Loss (Acoustic Trauma) 11/2021 - 01/2019
2	Deafness (Deaf Mutism) 05/2019 - 06/2002
2	Wounds and Injuries (Trauma) 01/2019 - 05/2011
2	Neoplasm Metastasis (Metastasis) 12/2013 - 01/2012
2	Infections 05/2011 - 10/2005
2	Necrosis 10/2004 - 05/2002
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2021
1	Hidden Hearing Loss 01/2019
1	Cystic Fibrosis (Mucoviscidosis) 01/2016
1	Presbycusis 02/2015
1	Cytomegalovirus Infections (Inclusion Disease) 02/2015
1	Sensorineural Hearing Loss 05/2011

Drug/Important Bio-Agent (IBA)

31	Cisplatin (Platino)FDA LinkGeneric 11/2021 - 05/2002
12	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2021 - 12/2003
10	Pharmaceutical PreparationsIBA 11/2021 - 08/2002
10	AntioxidantsIBA 11/2021 - 04/2003
8	AminoglycosidesIBA 01/2021 - 10/2003
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 10/2003
5	Protective AgentsIBA 01/2021 - 01/2005
5	Proteins (Proteins, Gene)FDA Link 05/2019 - 12/2008
5	Small Interfering RNA (siRNA)IBA 01/2018 - 12/2008
4	Antineoplastic Agents (Antineoplastics)IBA 05/2019 - 03/2003
4	Methionine (L-Methionine)FDA Link 01/2019 - 06/2002
4	N-(1-methyl-2-phenylethyl)adenosine (S-PIA)IBA 01/2019 - 05/2004
4	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2016 - 09/2010
4	PlatinumIBA 10/2005 - 08/2002
4	Carboplatin (JM8)FDA LinkGeneric 06/2005 - 08/2002
3	Adenosine (Adenocard)FDA LinkGeneric 01/2019 - 02/2004
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 05/2019 - 01/2017
2	ResveratrolIBA 01/2017 - 01/2012
2	Adenosine A1 ReceptorIBA 01/2017 - 04/2016
2	CytokinesIBA 01/2017 - 01/2006
2	PhenylisopropyladenosineIBA 04/2016 - 01/2010
2	Androgen Receptors (Androgen Receptor)IBA 12/2013 - 01/2012
2	SERPIN-B5 (maspin)IBA 12/2013 - 01/2012
2	MicroRNAs (MicroRNA)IBA 12/2013 - 01/2012
2	RNA (Ribonucleic Acid)IBA 01/2012 - 09/2010
2	Therapeutic UsesIBA 11/2009 - 10/2007
2	EnzymesIBA 10/2007 - 04/2003
2	Phosphates (Orthophosphate)IBA 01/2004 - 03/2003
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2021
1	Capreomycin (Capastat)FDA Link 01/2021
1	Erythromycin (Erycette)FDA LinkGeneric 01/2021
1	Gentamicins (Gentamicin)FDA LinkGeneric 01/2021
1	Peptides (Polypeptides)IBA 01/2021
1	Vancomycin FDA LinkGeneric 01/2021
1	Clarithromycin (Biaxin)FDA LinkGeneric 01/2021
1	Azithromycin (Zithromax)FDA LinkGeneric 01/2021
1	MacrolidesIBA 01/2021
1	CaspasesIBA 01/2021
1	GTP-Binding Proteins (G-Protein)IBA 05/2019
1	AMP-Activated Protein Kinase KinasesIBA 01/2019
1	kenpaulloneIBA 01/2019
1	SteroidsIBA 01/2019
1	MelatoninIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Etanercept (Enbrel)FDA Link 01/2019
1	Cyclin-Dependent Kinase 2IBA 01/2019
1	Caffeine (No Doz)FDA LinkGeneric 01/2019
1	pifithrinIBA 01/2019
1	iodopravadoline (AM 630)IBA 01/2018
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2018
1	Adenosine Triphosphatases (ATPase)IBA 01/2018
1	EndocannabinoidsIBA 01/2018
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2017
1	CannabinoidsIBA 01/2017
1	Long Noncoding RNAIBA 01/2017
1	Apoptosis Regulatory ProteinsIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 10/2016
1	STAT1 Transcription FactorIBA 10/2016
1	Tobramycin (Nebcin)FDA LinkGeneric 01/2016
1	Investigational DrugsIBA 02/2015
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 12/2013
1	OligonucleotidesIBA 01/2012
1	Capsaicin (Zostrix)FDA Link 03/2011
1	Protein Isoforms (Isoforms)IBA 09/2010
1	Messenger RNA (mRNA)IBA 01/2010
1	Ginkgo biloba extract (Rokan)IBA 09/2007
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2006
1	LipopolysaccharidesIBA 01/2006
1	Thioctic Acid (Lipoic Acid)IBA 06/2005
1	Oxidants (Oxidizing Agents)IBA 06/2005

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 01/2018 - 08/2002
3	Therapeutics 01/2019 - 05/2011
3	Injections 04/2016 - 03/2011
2	Oral Administration 01/2019 - 01/2012
1	Cochlear Implantation 11/2021
1	Intratympanic Injection 09/2010
1	Chemoprevention 04/2007